Multicentric reticulohistiocytosis with elevated cytokine serum levels
Identifieur interne : 001535 ( Main/Exploration ); précédent : 001534; suivant : 001536Multicentric reticulohistiocytosis with elevated cytokine serum levels
Auteurs : Antoni Bennàssar [Espagne] ; Antoni Mas [Espagne] ; Antonio Guilabert [Espagne] ; Marc Julià [Espagne] ; José Manuel Mascar Aly [Espagne] ; Carmen Herrero [Espagne]Source :
- The Journal of Dermatology [ 0385-2407 ] ; 2011-09.
English descriptors
- Teeft :
- Acad dermatol, Arch dermatol, Arthritis mutilans, Arthritis rheum, Association multicentric reticulohistiocytosis, Autoimmune disorders, Bennassar, Case report, Clin, Clin dermatol, Clinical features, Cutaneous, Cytokine, Cytokine serum levels, Dermatol, Dermatology, Dermatomyositis, Destructive polyarthritis, Diabetes mellitus, Extensor surfaces, Factor xiiia, Histiocyte, Immunohistochemical, Immunohistochemical analysis, Interleukin, Internal malignancies, Macrophage, Malignancy, Methotrexate, Monocyte, Multicentric, Multicentric reticulohistiocytosis, Multinucleated, Multinucleated giant cells, Ndings, Papule, Positive tuberculin test, Remission, Reticulohistiocytosis, Rheumatol, Serum levels, Skin biopsy, Skin involvement, Skin lesions, Successful treatment, Synovium, Tumor necrosis, Uncommon cell histiocytosis, Unknown etiology, Upper chest, Weight loss.
Abstract
Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.
Url:
DOI: 10.1111/j.1346-8138.2010.01146.x
Affiliations:
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features</term><term>Cutaneous</term><term>Cytokine</term><term>Cytokine serum levels</term><term>Dermatol</term><term>Dermatology</term><term>Dermatomyositis</term><term>Destructive polyarthritis</term><term>Diabetes mellitus</term><term>Extensor surfaces</term><term>Factor xiiia</term><term>Histiocyte</term><term>Immunohistochemical</term><term>Immunohistochemical analysis</term><term>Interleukin</term><term>Internal malignancies</term><term>Macrophage</term><term>Malignancy</term><term>Methotrexate</term><term>Monocyte</term><term>Multicentric</term><term>Multicentric reticulohistiocytosis</term><term>Multinucleated</term><term>Multinucleated giant cells</term><term>Ndings</term><term>Papule</term><term>Positive tuberculin test</term><term>Remission</term><term>Reticulohistiocytosis</term><term>Rheumatol</term><term>Serum levels</term><term>Skin biopsy</term><term>Skin involvement</term><term>Skin lesions</term><term>Successful treatment</term><term>Synovium</term><term>Tumor necrosis</term><term>Uncommon cell histiocytosis</term><term>Unknown etiology</term><term>Upper chest</term><term>Weight loss</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multicentric reticulohistiocytosis (MRH) is an uncommon non‐Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor‐α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate‐resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Bennassar, Antoni" sort="Bennassar, Antoni" uniqKey="Bennassar A" first="Antoni" last="Bennàssar">Antoni Bennàssar</name></region><name sortKey="Guilabert, Antonio" sort="Guilabert, Antonio" uniqKey="Guilabert A" first="Antonio" last="Guilabert">Antonio Guilabert</name><name sortKey="Herrero, Carmen" sort="Herrero, Carmen" uniqKey="Herrero C" first="Carmen" last="Herrero">Carmen Herrero</name><name sortKey="Julia, Marc" sort="Julia, Marc" uniqKey="Julia M" first="Marc" last="Julià">Marc Julià</name><name sortKey="Mas, Antoni" sort="Mas, Antoni" uniqKey="Mas A" first="Antoni" last="Mas">Antoni Mas</name><name sortKey="Mascar Aly, Jose Manuel" sort="Mascar Aly, Jose Manuel" uniqKey="Mascar Aly J" first="José Manuel" last="Mascar Aly">José Manuel Mascar Aly</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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